Contents Chapter 1: Introduction and History ... 1 Chapter 2: Medicinals of Plant Prigin: Historical Aspects ... 7 Chapter 3: Biopharmaceutical Properties of Drug Substances ... 12 Chapter 4: Structural Features and Pharmacologic Activity ... 25 Chapter 5: Theoretic Aspects of Drug Desing ... 50 Chapter 6: Molecular Modeling ... 58 Chapter 7: Receptors and Drug Actions ... 75 Chapter 8: Drug Metabolism ... 83 Chapter 9: Volatile Anesthetics ... 141 Chapter 10: Central Nervous System Depressant: Sedative-Hypnotics ... 154 Chapter 11: Anticonvulsants ... 182 Chapter 12: Neuroleptics and Anxiolytic Agents ... 199 Chapter 13: Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonism Agents and Skeletal Muscle Relaxants ... 232 Chapter 14: Anaslgesics ... 247 Chapter 15: Central Nervous System Stimulants ... 270 Chapter16: Local Anesthesics ... 305 Chapter 17: Cholinergic Agonists, Acetycholinesterase, Inhibitors, and Cholinergic Antagonists ... 321 Chapter 18: Adrenergic Drugs ... 345 Chapter 19: Cardiacs Agents: Cardiacs Glycosides ... 366 Chapter 20: Anticoagulant, Coagulants, and Plasma Extenders ... 388 Chapter 21: Diuretics ... 405 Chapter 22: Antiallergic and Antiulcer Drugs ... 416 Chapter 23: Cholesterol, Adrenocorticoids, and Sex Hormones ... 444 Chapter 24: Antipidemic Drugs ... 445 Chapter 25: Nosteroidal Anti-Inflammatory Drugs ... 535 Chapter 26: Drugs Affecting Sugar Metabolism ... 581 Chapter 27: Amino Acids, Peptides, and Proteins ... 601 Chapter 28: Pharmaceutical Biothecnology ... 622 Chapter 29: Vitamins and Coenzymes ... 652 Chapter 30: Thyroid function and Thyroid Drugs ... 688 Chapter 31: Metabolite Antagonism ... 705 Chapter 32: Parasite Chemotherapy ... 730 Chapter 33: Antymobacterial Agents ... 747 Chapter 34: Antibiotics and Antimicrobial Agents ... 759 Chapter 35: Antifugal Agents ... 803 Chapter 36: Antiseptics and Disinfectants ... 812 Chapter 37: Cancer Chemotherapy ... 822 Chapter 38: Antiviral Agents ... 846 Chapter 39: Approaches to Anti-Aids Agents ... 862 Chapter 40: Hormone Antagonists ... 877 Chapter 41 Photochjemotherapy ... 893 Chapter 42: Pesticides ... 908 Chapter 43: Agents for Organ Imaging ... 927 Appendix ... 948 Index ... 963 |
Principles of Medicinal Chemistry, 4/Ed. 1995 - 995pp William O. Foye, Thomas L. Lemke, David A. Williams
At the time of the first edition of this book, the role of the underlying biochemical interactions in the activity of drugs was
beginning to be understood. The concepts of receptor sites for drugs on protein, enzymes, and other macromolecules was
developing rapidly, but the specific chemical groups and functions responsible for interaction at a receptor site were still largely
undertermined. As knowledge about both chemistry and biology advanced, and the role of the computer in presenting drug-
receptor interactions was developed, a greater degree of complexity unfolded in many cases than simple models had
predicated. |