Contents

Chapter 1: Introduction and History ... 1

Chapter 2: Medicinals of Plant Prigin: Historical Aspects ... 7

Chapter 3: Biopharmaceutical Properties of Drug Substances ... 12

Chapter 4: Structural Features and Pharmacologic Activity ... 25

Chapter 5: Theoretic Aspects of Drug Desing ... 50

Chapter 6: Molecular Modeling ... 58

Chapter 7: Receptors and Drug Actions ... 75

Chapter 8: Drug Metabolism ... 83

Chapter 9: Volatile Anesthetics ... 141

Chapter 10: Central Nervous System Depressant: Sedative-Hypnotics ... 154

Chapter 11: Anticonvulsants ... 182

Chapter 12: Neuroleptics and Anxiolytic Agents ... 199

Chapter 13: Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonism Agents and Skeletal Muscle Relaxants ... 232

Chapter 14: Anaslgesics ... 247

Chapter 15: Central Nervous System Stimulants ... 270

Chapter16: Local Anesthesics ... 305

Chapter 17: Cholinergic Agonists, Acetycholinesterase, Inhibitors, and Cholinergic Antagonists ... 321

Chapter 18: Adrenergic Drugs ... 345

Chapter 19: Cardiacs Agents: Cardiacs Glycosides ... 366

Chapter 20: Anticoagulant, Coagulants, and Plasma Extenders ... 388

Chapter 21: Diuretics ... 405

Chapter 22: Antiallergic and Antiulcer Drugs ... 416

Chapter 23: Cholesterol, Adrenocorticoids, and Sex Hormones ... 444

Chapter 24: Antipidemic Drugs ... 445

Chapter 25: Nosteroidal Anti-Inflammatory Drugs ... 535

Chapter 26: Drugs Affecting Sugar Metabolism ... 581

Chapter 27: Amino Acids, Peptides, and Proteins ... 601

Chapter 28: Pharmaceutical Biothecnology ... 622

Chapter 29: Vitamins and Coenzymes ... 652

Chapter 30: Thyroid function and Thyroid Drugs ... 688

Chapter 31: Metabolite Antagonism ... 705

Chapter 32: Parasite Chemotherapy ... 730

Chapter 33: Antymobacterial Agents ... 747

Chapter 34: Antibiotics and Antimicrobial Agents ... 759

Chapter 35: Antifugal Agents ... 803

Chapter 36: Antiseptics and Disinfectants ... 812

Chapter 37: Cancer Chemotherapy ... 822

Chapter 38: Antiviral Agents ... 846

Chapter 39: Approaches to Anti-Aids Agents ... 862

Chapter 40: Hormone Antagonists ... 877

Chapter 41 Photochjemotherapy ... 893

Chapter 42: Pesticides ... 908

Chapter 43: Agents for Organ Imaging ... 927

Appendix ... 948

Index ... 963

Principles of Medicinal Chemistry, 4/Ed. 1995 - 995pp
William O. Foye, Thomas L. Lemke, David A. Williams

At the time of the first edition of this book, the role of the underlying biochemical interactions in the activity of drugs was beginning to be understood. The concepts of receptor sites for drugs on protein, enzymes, and other macromolecules was developing rapidly, but the specific chemical groups and functions responsible for interaction at a receptor site were still largely undertermined. As knowledge about both chemistry and biology advanced, and the role of the computer in presenting drug- receptor interactions was developed, a greater degree of complexity unfolded in many cases than simple models had predicated.
A variety of disciplines has attempted to describe and make clear these interactions, including pharmacology, molecular biology, biochemistry, and medicinal chemistry. The mechanisms of many drug substances can now be explained at the chemical level, but aspects from all of these disciplines are often interwoven to present a relatively complete picture of the various interactions and transformations involved in the course of events leading to drug activity. (...)

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