Chapter 1: Desing of asymmetric synthesis ... 1

Chapter 2: Non-linear effects in enantioselective synthesis: asymmetric amplification... 9

Chapter 3: Chiral enolates... 27

Chapter 4: Optically active B-ketosulfoxides in asymmetric synthesis... 60

Chapter 5: Chiral aminals in asymmetric synthesis... 93

Chapter 6: Asymmetric deprotonation reactions using enantiopure lithium amide bases... 111

Chapter 7: Asymmetric Diels-Ader reactions... 126

Chapter 8: Trasition metal catalysts for asymmetric reduction... 146

Chapter 9: Asymmetric hydroboration...181

Chapter 10: Asymmetric hydrosilylation and hydroformylation reactions... 212

Chapter 11: Asymmetric conjugate addition reactions... 222

Chapter 12: Stereoselective transformations mediated bychiral titanium complexes... 231

Chapter 13: Asymetric synthesis using enzymes and whole cells... 260

Chapter 14: Asymmetric palladium-catalysed coupling reactions...274

Chapter 15: Palladium allyl pi-complexes in asymmetric synthesis...299

Chapter 16: Stoichiometric pi-complexes in asymmetric synthesis... 313

Chapter 17: Asymmetric oxidation

Chapter 18: Worked examples in asymmetric synthesis desing... 392


Asymmetric synthesis is a branch of organic chemistry of crucial strategic importance to both the industrial and academic worlds, and the pace of development continues unabated. This bench-mark book reviews both well established and emerging techniques, d rawing on the experience of an international team of authors. Extensive reference to the primary and review literature makes it at once an authoritative overview of the subject and an essential one-stop reference source for organic and synthetic chemists.

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